Title : The islet - acinar axis of the pancreas : More than just insulin
نویسندگان
چکیده
Title: The islet-acinar axis of the pancreas: More than just insulin 1 2 Authors: Savio G Barreto , Colin J Carati , James Toouli , Gino TP 3 Saccone 1 4 5 6 Institution: 1 Department of General and Digestive Surgery, 2 Department of 7 Anatomy and Histology, Flinders Medical Centre and Flinders University, 8 Adelaide, South Australia, Australia 9 10 Total pages (excl. Title page) = 33 11 Abstract word count (250 limit) = 213 12 Nature of the Manuscript: Review Paper 13 Word count (excluding references) = 4767 words 14 Conflict of interest: none 15 16 Running head: Islet-acinar axis 17 18
منابع مشابه
The islet-acinar axis of the pancreas: more than just insulin.
Although the role of the islets in the regulation of acinar cell function seemed a mystery to investigators who observed their dispersion among pancreatic acini, over time an appreciation for this intricate and unique structural arrangement has developed. The last three decades have witnessed a steadily growing understanding of the interrelationship of the endocrine and the exocrine pancreas. T...
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The well known hypertrophy of the rat exocrine pancreas caused by dietary soybean trypsin inhibitor (STI) has now been shown to be accompanied by an increased prominence of acinar-/? intermediate cells and a reduction in the size of the islets of Langerhans. The acinar-/? cells are situated in the exocrine tissue surrounding the islets where the acinar cells in STI-fed rats show a greater numbe...
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Background: Type 1 diabetes (T1D) is a T-cell mediated autoimmune disorder in which pancreas beta-cell destruction causes insulin deficiency and hyperglycemia. In addition to daily insulin treatment, allogeneic islet transplant inT1D is another therapeutic way that needs immunosuppressive drugs to control autoimmune damage and graft rejection. Since life-long application of these drugs is ...
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Objective(s): The use of a co-culture of islets with mesenchymal stromal cells (MSCs) is a promising therapy in islet transplantation to revert hyperglycaemia, but the resulting insulin-producing cells (IPCs) express low levels of pancreas endocrine developmental genes. This study aims to investigate the morphochronology of a co-culture of islets with MSCs from injured adult pancreata, and char...
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